Executive Medical Director
Board Certified in Psychiatry and Addiction Medicine
Link to Recent Published Research Studies
Michael Mamoun, M.D. is a neuroscientist and physician specializing in psychiatry, neuroimaging, and brain stimulation. He is actively involved in clinical practice as well as research. Dr. Mamoun completed his residency training at the Neuropsychiatric Institute of the UCLA Medical Center. UCLA is consistently ranked in the top #1-3 institutions for psychiatry training internationally. He has been consecutively voted as a top doctor by US News & Health Report and by Los Angeles Magazine.
As an Interventional Psychiatrist, Dr. Mamoun is especially skilled in treating challenging cases which have been referred to him by leading medical institutions and colleagues, nationwide. He is experienced in a very wide range of treatment options, including traditional ones such as prescription medications, herbs & supplements, and psychotherapy. He is also skilled in more advanced treatments such as ketamine administration, and numerous brain stimulation therapies (including fMRI-guided TMS, TBS, VNS, TNS, and tDCS). He is skilled in a wide range of diagnostic assessment (including psychodiagnostic & neurocognitive testing, and neuroimaging).
Clinically, Dr. Mamoun is experienced in treating the entire spectrum of mental health conditions, including depression, anxiety, bipolar disorder, and ADHD. He is also skilled in treating substance abuse disorders, including smoking, prescription drug dependence & recreational drug use. He routinely treats a wide range of conditions, ranging from simple depression to very challenging and treatment-refractory neuropsychiatric conditions referred by colleagues nationwide. Dr. Mamoun also provides mentoring & supervision to numerous psychiatrists, and teaches at several international neuroscience conferences.
In addition to traditional psychiatric treatment, when clinically-indicated, he sometimes incorporates modern technological tools in order to assist in diagnosis and treatment of challenging cases. This includes pharmaco-genetic testing, sophisticated neuroimaging, and fMRI-guided TMS. His experience in neuroimaging includes: CT, PET, MRI, DTI, MRS, and fMRI (functional MRI) – including 3D MPRage, Resting BOLD, and ASL. He is one of the first psychiatrists in the country to collaborate with neurologists and neuroradiologists in offering neuroimaging-based, fMRI-guided multi-site TMS (magnetic stimulation of the brain) in order to treat psychiatric conditions in a novel way.
Academically, Doctor Mamoun has been involved in neuroimaging brain research dating all the way back to his undergraduate years. For some time, Dr. Mamoun’s research focused on drug addiction through the UCLA and VA Medical Centers. His research projects utilize brain imaging in order to better understand the nature of psychiatric conditions and drug addictions. One such study, recently published in JAMA (Journal of the American Medical Association) Psychiatry (Link), showed how functional neuroimaging can be used to help predict psychiatric treatment response. It has since been cited in numerous studies and conferences. More recently, his research projects have focused on very new treatment modalities such as fMRI-guided TMS, and Ultrasound brain stimulation.
Dr. Mamoun has previously served as the Director of Psychiatric Services at Homeless Healthcare Los Angeles and has volunteered at the non-profit Venice Family Clinic.
Member, American Psychiatric Association
Member, American Society for Functional Neuroradiology
Member, Clinical TMS Society
Member, Brain Stimulation
Recently published research studies:
Improved rTMS efficacy after fMRI localizes DLPFC target to non-dominant hemisphere
Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression
Focused Transcranial Ultrasound for Treatment of Neurodegenerative Dementia
Effects of fMRI navigated TMS on treatment outcomes in major depressive disorder
fMRI correlates of cognitive reappraisal to identify additional TMS targets for Generalized Anxiety
Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 PET Study
Journal of Neuropsychopharmacology
Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use.
Journal of Psychopharmacology
Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date
Journal of CNS Drugs
Radiation dosimetry and biodistribution of the translocator protein radiotracer [(11)C]DAA1106 determined with PET/CT in healthy human volunteers.
Journal of Nuclear Medicine and Biology
Brain Nicotinic Acetylcholine Receptor Availability and Response to Smoking Cessation Treatment: A Randomized Trial.
JAMA (Journal of the American Medical Association) Psychiatry. MRI & PET brain imaging study.
Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.
Neuropsychopharmacology. 2013 Jul;38(8):1548-56. PET neuroimaging study.
Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers
International Journal of Neuropsychopharmacology. 2013 Jun;16(5):957-66. PET neuroimaging study.